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KMID : 0379520230390030341
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한국독성학회지
2023 Volume.39 No. 3 p.341 ~ p.353
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Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases
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Thuy-Trang T. Vo
Kong Gye-Yeong
Kim Chae-Yeong
Juang Ui-Jin
Gwon Su-Hwan
Shuai Qiu
Huonggiang Nguyen
Kim Seon-Hwan
Park Jong-Sun
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Abstract
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Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.
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KEYWORD
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Scavenger receptor class F member 2, SCARF2, Cancer, Biomarker, Van den Ende?Gupta syndrome(VDEGS), Glioblastom
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